Guardiola admitted Kompany's injury history is a concern but remains hopeful the club's captain will sign a contract extension before his current deal expires this summer.
"We are talking about that - I would like it," Guardiola said, according to the Guardian's Jamie Jackson. "He's our captain, 11 years here, we saw in the last two (league) games the huge quality and personality he has to play. The only problem with Vincent is one: his injury problems."
Kompany will be 33 when his contract expires. The center-back has been limited to just 12 Premier League appearances this term due to injuries, as well as his manager's preference to deploy John Stones and Aymeric Laporte in the heart of City's back line.
But Guardiola continues to hold the Belgian international in high regard, citing Kompany's relentless determination as a quality that sets him apart.
"One against one absolutely we're better when Vincent plays," he said. "Laporte has a better left foot - every central defender has his own quality - but there's no doubt Vincent has something special with his charisma, winning the duels.
"It's incredible, he's one of the best central defenders I've ever seen. The problem is whether he's fit."
Since transferring to City from Hamburg in 2008, Kompany has been an integral member of the most successful teams in club history; he's lifted the Premier League trophy three times and helped City capture the FA Cup along with three League Cup titles.