San Francisco 49ers edge rusher Nick Bosa is expected to miss a few weeks after pulling his calf during Thursday's practice, sources told ESPN's Adam Schefter and Ian Rapoport.
The 49ers are reportedly still determining whether Bosa will need to go on injured reserve.
If he lands on IR, he'll have to miss at least four games.
Bosa is the latest injury to plague the 49ers, with the team placing defensive tackle C.J. West on the IR this week.
The 49ers now have seen six defensive linemen go down in the past two weeks:
— Adam Schefter (@AdamSchefter) September 25, 2026
🏈Nick Bosa (calf; expected to miss at least a few weeks)
🏈Alfred Collins (torn patellar tendon, season-ending)
🏈Sam Okuayinonu (broken foot)
🏈James Thompson Jr. (high-ankle sprain)
🏈Romello Height… pic.twitter.com/XvdDg8x8HC
Veteran wide receiver Mike Evans has also been nursing a hip injury, while wideout Demarcus Robinson is dealing with a high ankle sprain. Rookie receiver De'Zhaun Stribling underwent ankle surgery after Week 1.
Bosa spent the offseason working toward a return after tearing his ACL in Week 3 last season. He recorded zero sacks and two tackles for a loss in two games before pulling his calf.
A former Defensive Player of the Year winner, Bosa has been one of the NFL's most dangerous edge rushers when healthy. He posted 44.5 sacks between 2021 and 2023.
